Thomas Graham


Postdoctoral Researcher

Transcription Regulation at the Polytene Chromosomes


I’m developing new approaches to study transcription regulation using Drosophila polytene chromosomes. These remarkable structures consist of 1024 copies of the same chromatid aligned in parallel, which makes it possible to resolve binding of fluorescently labeled proteins to specific locations on the genome.  My goal is to employ advanced genome editing and imaging tools in this distinctive system to study enhancer and promoter function with single-molecule resolution.