Rett syndrome (RTT) is an X-linked neurological regressive disorder caused in >95% of the cases by mutations in the methyl-CpG binding protein 2 (MECP2) gene. MeCP2 binds methylated DNA via its methyl-CpG binding domain (MBD) and recruits co-repressor complexes via its transcriptional repression domain. Both domains are hot spots for RTT mutations.
In collaboration with Huda Zoghbi’s lab at Baylor College of Medicine I am studying the effects of RTT-causing mutations on MeCP2 dynamic behavior, using various live-cell imaging technologies, including single molecule tracking.
In addition to my own project, I also provide technical and scientific support to our postdocs, grad and undergrad students, and work with the rest of the staff to keep the boat sailing.
I have also worked in closer collaboration with some people in the lab to move certain projects forward, contributing my Molecular Biology, Genomics, Biochemistry, Cell & Animal biology and manuscript editing skills.
I love the science and I love the people.