Research Spotlight

Mammalian interphase genomes are functionally compartmentalized into topologically associating domains (TADs) spanning hundreds of kilobases. TADs are defined by frequent chromatin interactions within themselves and they are insulated from adjacent TADs. Most TAD or domain...
Basal transcription factors like TFIID, also known as general transcription factors, are proteins that can bind gene promoters and recruit RNA polymerase II to allow transcription initiation. Recent lines of evidence using terminally differentiated cells...
Overview: Gene activation by transcription factors (TFs) is one of the most fundamental processes in a cell. In order to maintain cell homeostasis, properly respond to stress signals, or differentiate into a new cell type,...
Chromatin organization and transcription regulations Chromatin packages eukaryotic genomes via a hierarchical series of folding steps, encrypting multiple layers of genetic and epigenetic information such as histone modifications and 3D chromatin organization, which are capable...
Sequence specific DNA-binding transcription factors (TFs) are seminal players in eukaryotic gene regulation. From the earliest studies of human TFs it was recognized that regulatory proteins like Sp1 contain well-structured DNA binding domains (DBDs) and...
Heterodimeric transcription factors are ubiquitous in eukaryotes. In cases such as that of the bHLHZ, bZIP, and type II nuclear receptors, such proteins associate into complex regulatory networks that have been difficult to dissect with...
Viruses, by their very nature, are evolved to hijack cellular processes to their own advantage. This essential feature, which can make them to troublesome as a pathogen, also has the potential to reveal new insight...
Transcriptional dynamics in developing embryos at the single molecule level During animal development the fate of individual cells in the early embryo are decided with exquisite spatial and temporal precision. At the molecular level these...