Research

Dynamic and selective low-complexity domain interactions and their roles in transcription and cancer
Sequence specific DNA-binding transcription factors (TFs) are seminal players in eukaryotic gene regulation. From the...
Chromatin organization and transcription regulations
Chromatin packages eukaryotic genomes via a hierarchical series of folding steps, encrypting multiple layers of...
Cell Identity Establishment and Maintenance
Basal transcription factors like TFIID, also known as general transcription factors, are proteins that can...
Elucidating mechanisms and dynamics of gene activation by the interplay between RNA Polymerase II, GTFs and co-activators
Gene activation by transcription factors (TFs) is one of the most fundamental processes in a...
Competitive binding kinetics of type II nuclear receptors in live cells
Heterodimeric transcription factors are ubiquitous in eukaryotes. In cases such as that of the bHLHZ,...
Single Molecule Transcriptional Dynamics in Developing Embryos
Transcriptional dynamics in developing embryos at the single molecule level During animal development the fate...