Research

Single molecule dynamics of transcription factors driving 
human embryonic stem cell differentiation
Development and differentiation involve massive and often rapid changes in transcription activity, chromatin landscape as...
Cell Identity Establishment and Maintenance
Basal transcription factors like TFIID, also known as general transcription factors, are proteins that can...
Dynamics of 3D genome organization: the role of CTCF and cohesin
Mammalian interphase genomes are functionally compartmentalized into topologically associating domains (TADs) spanning hundreds of kilobases....
Competitive binding kinetics of type II nuclear receptors in live cells
Heterodimeric transcription factors are ubiquitous in eukaryotes. In cases such as that of the bHLHZ,...
Chromatin organization and transcription regulations
Chromatin packages eukaryotic genomes via a hierarchical series of folding steps, encrypting multiple layers of...
Virus-mediated reorganization of the nucleus
Viruses, by their very nature, are evolved to hijack cellular processes to their own advantage....
Elucidating mechanisms and dynamics of gene activation by the interplay between RNA Polymerase II, GTFs and co-activators
Gene activation by transcription factors (TFs) is one of the most fundamental processes in a...
Dynamic and selective low-complexity domain interactions and their roles in transcription and cancer
Sequence specific DNA-binding transcription factors (TFs) are seminal players in eukaryotic gene regulation. From the...
Single Molecule Transcriptional Dynamics in Developing Embryos
Transcriptional dynamics in developing embryos at the single molecule level During animal development the fate...