_____________________________________________________________________________

Rett syndrome (RTT) is a rare X-linked genetic disorder causing severe neurological impairment. It primarily occurs in girls, while boys typically die shortly after birth. RTT is caused by mutations in the methyl-CpG binding protein 2 (MeCP2), an epigenetic regulator mostly involved in transcriptional silencing. During my research, I am investigating the molecular mechanisms underlying Rett syndrome using live, single-cell, super-resolution microscopy of wild-type and a pathological version of MeCP2.