TFIID is composed of the TATA-binding protein TBP and several TBP-associated factors (TAFs). We have recently shown that a non-canonical TAF variant (TAF9B) regulates gene expression during murine motor neuron development. We are now investigating the role of TAF9B in the mouse adult brain, where TAF9B is highly and widely expressed across different regions. Preliminary data by others and us indicate that Taf9b expression is enriched in oligodendrocyte progenitor cells and newly formed oligodendrocytes compared to neurons and other glial cells. We are currently assessing the functional significance of such enrichment using both in vitro and in vivo models of oligodendrogenesis in wild type and Taf9b-/- backgrounds. The project is in collaboration with Aaron Friedman, a graduate student in the Daniela Kaufer lab at UC Berkeley.